We looked into the research and chatted with a couple of experts to get their take. You can ingest chlorophyll directly from plants, algae, and sea vegetables (chlorella, parsley, and spinach all contain significant amounts) or via supplements. Most supplements contain a chlorophyll derivative called chlorophyllin—often listed as sodium copper chlorophyllin on the ingredient list—that’s water-soluble and better absorbed by the body. Most research on the potential health benefits of chlorophyll has been performed with chlorophyllin. Though it’s not clear whether chlorella’s chelating (i.e., heavy-metal-binding) properties come solely from chlorophyll or from a combination of compounds. While the exact cancer-fighting mechanisms are unclear, early research3 shows that chlorophyll may reduce the risk of liver damage caused by aflatoxins (dangerous cancer-causing compounds produced by fungi that may be present on a variety of foods, including peanuts) by activating certain enzymes. In lab studies4, chlorophyll has also shown some promise in helping the immune system fight colon cancer cells. How significant these effects are is not yet clear, but it’s the reason some people choose to supplement with chlorophyll after flights, as we are exposed to increased levels of radiation during air travel7. Research on this is mixed, but one study8 found that chlorophyll supplementation reduced the number of trimethylamines in people with a condition called trimethylaminuria—a condition that causes a fishy odor due to an inability to break down trimethylamines. While there have been a number of other claims made regarding the health benefits of chlorophyll, there’s just not enough evidence at this time to back them up. Both may be somewhat beneficial for your health, but going for bottled chlorophyll drinks may be a waste of money (since you’re getting a lower concentration than you’d get in a supplement)—not to mention a waste of plastic. So if you want to get in on the trend, a DIY approach makes the most sense. “Liquid chlorophyll comes in a tincture, and you can add a few drops to some water in the morning,” says Cannon. Both Cannon and Will Cole, D.C., IFMCP, a functional medicine practitioner, emphasize the importance of quality when selecting a chlorophyll supplement (or any dietary supplement for that matter). Look for chlorophyll supplement brands without binders or fillers. You can also take a chlorella powder supplement or tablet, which naturally contains chlorophyll and a variety of other nutrients. The best time of day to take chlorophyll is really any time of day—it shouldn’t disrupt your sleep routine.